期刊
KIDNEY INTERNATIONAL
卷 94, 期 5, 页码 855-857出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2018.07.010
关键词
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Risk (or susceptibility) alleles for primary membranous nephropathy exist within the DQ and DR loci of the human leukocyte antigen (HLA) region of chromosome 6. The discussed study identifies a novel allele, HLA DRB1*1502, in a Han Chinese cohort that acts as a modifier allele by associating not with the phenotype of membranous nephropathy, but rather with the severity of disease. This commentary addresses the potential biologic aspects of these new data. Copyright (C) 2018, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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