期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 74, 期 11, 页码 1747-1752出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glz009
关键词
Amyloid; Frailty; Aging; Dementia; Brain regions
资金
- French Ministry of Health
- Gerontopole of Toulouse
- Pierre Fabre Research Institute
- Exhonit Therapeutics SA
- Avid Radiopharmaceuticals
- French National Agency for Research [ANR-11-LABX-0018-01]
- University Hospital Center of Toulouse
- Association Monegasque pour la Recherche sur la maladie d'Alzheimer (AMPA)
- UMR 1027 Unit INSERM-University of Toulouse III
Background We sought to determine whether cortical and regional beta-amyloid (A beta) were cross-sectionally and prospectively associated with change in frailty status in older adults. Methods We used data from 269 community-dwelling participants from the Multidomain Alzheimer's Preventive Trial (MAPT) who were assessed for brain A beta using positron-emission tomography scan. Regional and cortical-to-cerebellar standardized uptake value ratios were obtained. Frailty was assessed by a frailty index composed of 19 items not directly linked to cognition and Alzheimer's disease. Results A significant and positive cross-sectional and prospective relationship was found for A beta in the anterior putamen (cross-sectional: beta = 0.11 [0.02-0.20], p = .02; prospective: beta = 0.11 [0.03-0.19], p = .007), posterior putamen (cross-sectional: beta = 0.12 [0.009-0.23], p = .03; prospective: beta = 0.11 [0.02-0.21], p = .02), and precuneus regions (cross-sectional: beta = 0.07 [0.01-0.12], p = .01; prospective: beta = 0.07 [0.01-0.12], p = .01) with increasing frailty. Conclusions This study has found new information regarding cross-sectional and prospective positive associations between region-specific brain A beta deposits and worsening frailty. The potential mechanisms involved require further investigation.
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