期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 44, 页码 29899-29905出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b07838
关键词
near-infrared; organic dye; photothermdl therapy; nanoparticle; cancer
资金
- Ministry of Science and Technology [2014ZX09304307001, 2013ZX09507005]
- Natural Science Foundation of China [21621003, 21235004, 21175080]
- Program for International S&T Cooperation Projects of China [2011DFA31860]
Given their easy structural modification and good biocompatibility advantages, near-infrared (NIR) organic dyes with a large molar extinction coefficient, while a superlow fluorescence quantum yield shows considerable potential application in photothermal therapy (PTT). Herein; a new NIR-absorbing asymmetric cyanine dye, namely, RC, is designed and synthesized via the hybrid: of rhodamine and hemicyanine derivatives. RC-BSA nanoparricles (NPs) are fabricated by using the bovine serum albumin (BSA) matrix. The NPs exhibit a strong NIR absorption peak at similar to 868 nm and 28.7% photothermal conversion efficiency. Based on these features, RC-BSA NPs exhibit excellent performance in ablating tumor under 915 nm laser radiation through a PTT mechanism. These NPs show no obvious toxicity to the treated mice. Thus; RC-BSA NPs can used as,a new NIR laser-triggered PTT agent in cancer treatment.
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