期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1847, 期 9, 页码 968-985出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2015.05.007
关键词
Tetrapyrrole biosynthesis; photosynthetic pigments; posttranslational control; primary metabolism and photosynthesis; retrograde signaling; plastid and thylkoid biogenesis
资金
- Deutsche Forschungsgemeinschaft [Gr 936/18-1, Gr 936/15-2]
Tetrapyrroles are macrocyclic molecules with various structural variants and multiple functions in Prokaryotes and Eukaryotes. Present knowledge about the metabolism of tetrapyrroles reflects the complex evolution of the pathway in different kingdoms of organisms, the complexity of structural and enzymatic variations of enzymatic steps, as well as a wide range of regulatory mechanisms, which ensure adequate synthesis of tetrapyrrole end-products at any time of development and environmental condition. This review intends to highlight new findings of research on tetrapyrrole biosynthesis in plants and algae. In the course of the heme and chlorophyll synthesis in these photosynthetic organisms, glutamate, one of the central and abundant metabolites, is converted into highly photoreactive tetrapyrrole intermediates. Thereby, several mechanisms of posttranslational control are thought to be essential for a tight regulation of each enzymatic step. Finally, we wish to discuss the potential role of tetrapyrroles in retrograde signaling and point out perspectives of the formation of macromolecular protein complexes in tetrapyrrole biosynthesis as an efficient mechanism to ensure a fine-tuned metabolic flow in the pathway. (C) 2015 Elsevier B.V. All rights reserved.
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