A novel sensitive and reliable electrochemical determination of palmatine based on CeO2/RGO/MWCNT ternary composite

A sensitive and reliable electrochemical determination of natural alkaloid palmatine was proposed based on CeO2/RGO/MWCNT ternary composite modified screen printed carbon electrode. The proposed ternary composite was prepared via simple hydrothermal synthesis method without using of hazardous chemicals. The surface morphology, elemental compositions, functional group moieties, crystalline structure and defects and disorder of the prepared CeO2/RGO/MWCNT ternary composite was confirmed by various spectrometric techniques. In addition, the electrochemical properties of the modified electrodes were investigated by voltammetry techniques. Notably, the proposed CeO2/RGO/MWCNT modified electrode exhibited two linear concentration ranges from 0.1 to 118 mu M and 118 to 1198 mu M with the lowest detection limit of 0.03 mu M for the determination of palmatine at neutral condition. Additionally, the proposed electrode material showed a good sensitivity of 1. 791 mu A mu M-1 cm(-2) and detects the palmatine with good selectivity in the presence of interfering substances. Furthermore, the practical feasibility of the sensor was analyzed in human serum and urine samples. (C) 2018 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.