Utilization of thioacetanilides in the synthesis of new 4-(4-acetamidophenylazo)thiophene scaffolds and evaluating their anti-oxidant activity

The aim of this study involves the synthesis of novel heterocyclic scaffolds containing acetanilide moiety from the readily accessible 2-substituted-2-(4-acetamidophenylhydrazono)-thioacetanilides, which underwent reaction with various alpha-halogenated reagents (namely: bromoacetone, phenacyl bromide, ethyl bromoacetate and chloroacetonitrile) afforded the corresponding thiophene derivatives 5, 7 and 9. All freshly synthesized scaffolds were elucidated by considering the data of both elemental and spectral analyses. The synthesized scaffolds were screened for anti-oxidant activities and showed promising results.