期刊
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
卷 16, 期 3, 页码 437-447出版社
SPRINGER
DOI: 10.1007/s13738-019-01604-7
关键词
Peroxynitrite; Imaging; Fluorescent probes; Nanoparticles
资金
- Double First-rate subject-Food Science and Engineering Program of Heibei Province [2018SPGCA18]
- Young Tip-top Talents Plan of Universities and Colleges in Hebei Province of China [BJ2017026]
- Specific Foundation for Doctor in Hebei Agriculture University of China [ZD201709]
Peroxynitrite (ONOO-), known as a kind of reactive nitrogen species, is a significant factor involved in a broad spectrum of physiological and pathological processes. However, their biological functions remain to be controversial or poorly characterized yet, mainly because of the lack of reliable methods for sensitive and specific detection of ONOO- in vitro and in vivo. Thus, approaches that enable noninvasive visualized imaging of ONOO- will be of enormous benefit in understanding the processes of related diseases and developing novel drugs. During the last decades, fluorescent probes, with high sensitivity and real-time spatial imaging capacity, receive more and more attention. Herein, we strive to summarize the current fluorescent probes for ONOO-, including small-molecular fluorescent probes, nanoparticles-based fluorescent probes, and genetically encoded fluorescent probes. Furthermore, the challenges and attempt to give an outlook on the possible further developments are discussed.
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