期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 44, 页码 29883-29892出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b07715
关键词
photosensitizers; aggregation-induced emission enhancement; reactive oxygen species; mitochondrial dysfunction; chemo-phototherapy
资金
- Ministry of Science and Technology of ROC [MOST 104-2119-M-005-007-MY3]
Unlike traditional binary nanostructures that construct chemotherapy drugs and photodynamic therapy photosensitizers, we introduce a molecule with a chemo-photodynamic dual therapy function. A water-soluble aggregation-induced emission enhancement (AIRE) fluorogen, NV-12P, was designed and synthesized based on asymmetric 1,6-disubstituted naphthalene and can generate particular reactive oxygen species to undergo type I photodynamic therapy under irradiation. Furthermore, this compound can specifically localize in mitochondria and, after biological evaluation, can cause mitochondrial dysfunction and potent cytotoxicity to cancer cells but not normal cells. We conclude that this compound is a potential dual-toxic, efficacy molecule because it exhibits selective dark cytotoxicity and efficient photodamage in cancer cells. Additionally, we also supported the optimal combinational treatment course for the best chemo-phototherapy efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据