期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 72, 期 19, 页码 2380-2390出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2018.08.2161
关键词
arteriosclerosis; bioinformatics; genetic knockout models; genetics; noncoding RNA
资金
- [HL128822]
- [HL139549]
- [DK118086]
- [469LRRLBWF]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL139549, K08HL128822] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK118086] Funding Source: NIH RePORTER
Atherosclerosis is a complex and chronic disease characterized by lipid deposition in the vessel wall that leads to an inflammatory and proliferative cascade involving smooth muscle, endothelial, and immune cells. Despite substantial improvements in our understanding of mechanisms contributing to atherosclerosis and overall reduction in cardiovascular mortality, the absolute disease burden remains substantially high. The recent discovery of a new group of mediators known as long noncoding ribonucleic acids (lncRNAs) offers a unique opportunity for the development of novel diagnostic and therapeutic tools in atherothrombotic disease. A number of studies suggest that lncRNAs are important mediators in health and disease, and rapidly accumulating evidence implicates lncRNAs in regulatory circuits controlling atherosclerosis. In this review, the authors outline important contributions of lncRNAs to atherosclerosis and its associated risk factors, including hypercholesterolemia, diabetes, hypertension, and obesity. (c) 2018 by the American College of Cardiology Foundation.
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