期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 72, 期 18, 页码 2181-2197出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2018.08.2147
关键词
atherosclerosis; cardiovascular; inflammation; macrophage; resolution
资金
- National Institutes of Health [P01 HL131481, P01HL131478, R01 HL084312, R01 HL129433, DK095684, R35HL135799, R01HL075662, R01HL127464, R01HL132412, NIH NHLBI R01HL125863, NIH/NCATS R21 TR001739, R01HL130423]
- Department of Defense [W81XWH-16-1-0374]
- Leducq Foundation
- American Heart Association [A14SFRN20840000, 17FTF33660643, 14SFRN20490315, 14SFRN20840000]
- Leducq Foundation (Transatlantic Network of Excellence Award)
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [R21TR001739] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL125863, R35HL135799, R01HL075662, P01HL131481, P01HL131478, R01HL132412, R35HL145228, R01HL127464, R01HL084312, R01HL129433, R01HL130423] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK095684] Funding Source: NIH RePORTER
Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall. These modified lipoproteins activate resident macrophages and the recruitment of monocyte-derived cells, which differentiate into mononuclear phagocytes that ingest the deposited lipoproteins to become foam cells: a hallmark of this disease. In this Part 2 of a 4-part review series covering the macrophage in cardiovascular disease, we critically review the contributions and relevant pathobiology of monocytes, macrophages, and foam cells as relevant to atherosclerosis. We also review evidence that via various pathways, a failure of the resolution of inflammation is an additional key aspect of this disease process. Finally, we consider the likely role played by genomics and biological networks in controlling the macrophage phenotype in atherosclerosis. Collectively, these data provide substantial insights on the atherosclerotic process, while concurrently offering numerous molecular and genomic candidates that appear to hold great promise for selective targeting as clinical therapies. (c) 2018 Published by Elsevier on behalf of the American College of Cardiology Foundation.
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