期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 9, 页码 5747-5751出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11415
关键词
stimuli-response; molecularly imprinting; epitope; controllable release; protein
资金
- National Basic Research Program of China [2012CB910601]
- National Natural Science Foundation of China [21375128, 21190043]
- Creative Research Group Project of NSFC [21321064]
Among various artificial antibodies, epitope imprinted polymer has been paid increasingly attention. To modulate the adsorption and release behavior by environment stimuli, N-isopropylacrylamide, was adopted to fabricate the thermoresponsive epitope imprinted sites. The prepared imprinted materials could adsorb 46.6 mg/g of target protein with the imprinting factor of 4.0. The template utilization efficiency could reach as high as 8.21%. More importantly, in the real sample, the materials could controllably capture the target protein from the human plasma at 45 degrees C and release it at 4 degrees C, which demonstrated the on-demand application potentials of such materials in the biomolecule recognition field.
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