期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 41, 页码 27474-27481出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b06466
关键词
hydrogen sulfide; electrospinning; fibrous materials; polycaprolactone; controlled release; wound healing
资金
- Wenzhou Science & Technology Bureau of China [Y20140727]
- Zhejiang Provincial Natural Science Foundation of China [LQ15E030003]
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences [YKFJ001]
- NIH [R01HL116571]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
- NSF [ECCS-1509076]
Hydrogen sulfide (H2S), together with nitric oxide and carbon monoxide, has been recognized as an important gasotransmitter. It plays an essential physiological role in regulating cyto-protective signal process, and H2S-based therapy is considered as the next generation of promising therapeutic strategies for many biomedical applications, such as the treatment of cardiovascular disease. Through electrospinning of polycaprolactone (PCL) containing JK1, a novel pH-controllable H2S donor, nanofibers with H2S releasing function, PCL-JK1, are fabricated. This fibrous scaffold showed a pH-dependent H2S releasing behavior, i.e., lower pH induced greater and faster H2S release. In addition, the H2S release of JK1 was prolonged by the fibrous matrix as shown by decreased releasing rates compared to JK1 in solutions. In addition, in vitro studies indicated that PCL-JK1 exhibited excellent cyto-compatibility, similar to PCL fibers. Finally, we investigated PCL-JK1 as a wound dressing toward a cutaneous wound model in vivo and found that PCL-JK1 could significantly enhance the wound repair and regeneration compared with the control PCL scaffold, likely due to the release of H2S, which results in a broad range of physiologically protective functions toward the wound.
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