期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 4, 页码 1489-1493出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b13367
关键词
-
We report the first enantio- and diaster-eoselective 1,4-addition of butenolides to chromones. Both alpha,beta- and beta,gamma-butenolide nucleophiles are compatible with the Zn-ProPhenol catalyst, and preactivation as the siloxyfurans is not required. The scope of electrophiles includes a variety of substituted chromones, as well as a thiochromone and a quinolone, and the resulting vinylogous addition products are generated in good yield (31 to 98%), diastereo- (3:1 to >30:1), and enantioselectivity (90:10 to 99:1 er). These Michael adducts allow rapid access to several natural product analogs, and can be easily transformed into a variety of other interesting scaffolds as well.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据