期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 2, 页码 739-742出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b09811
关键词
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资金
- NIH [R35 GM125029]
- Sloan Foundation [FG-2016-6568]
- University of Illinois
A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.
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