期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 6, 页码 2636-2644出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b12965
关键词
-
资金
- MOST [2016YFA0202900]
- NSFC [21772219, 21821002, 21801248]
- Science and Technology Commission of Shanghai Municipality [16XD1404300, 18QA1404900, 18YF1428900, 16490712200]
- Chinese Academy of Sciences [XDB20000000, QYZDY-SSW-SLH012]
- Youth Innovation Promotion Association of CAS [2017302]
An intramolecular dearomatization of indole derivatives based on visible-light-promoted [2+2] cyclo-addition was achieved via energy transfer mechanism. The highly strained cyclobutane-fused angular tetracyclic spiroindolines, which were typically unattainable under thermal conditions, could be directly accessed in high yields (up to 99%) with excellent diastereoselectivity (>20:1 dr) under mild conditions. The method was also compatible with diverse functional groups and amenable to flexible transformations. In addition, DFT calculations provided guidance on the rational design of substrates and deep understanding of the reaction pathways. This process constituted a rare example of indole functionalization by exploiting visible-light-induced reactivity at the excited states.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据