期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 50, 页码 17666-17673出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b10069
关键词
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资金
- National Natural Science Foundation of China [21772150]
- Wuhan University of Technology
Direct synthesis of alkynes from inexpensive, abundant alcohols was achieved in high yields (greater than 40 examples, up to 95% yield) through a SO2F2-promoted dehydration and dehydrogenation process. This straightforward transformation of sp(3)-sp(3) (C-C) bonds to sp-sp (C C) bonds requires only inexpensive and readily available reagents (no transition metals) under mild conditions. The crude alkynes are sufficiently free of impurities to permit direct use in further transformations, as illustrated by regioselective Huisgen alkyne-azide cycloaddition reactions with PhN3 to give 1,4-substituted 1,2,3-traiazoles (16 examples, up to 92% yield) and Sonogashira couplings (10 examples, up to 77% yield).
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