期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 1, 页码 684-692出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b12206
关键词
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资金
- Natural Sciences and Engineering Council of Canada (NSERC)
- Canada Foundation for Innovation (CFI)
- University of Calgary
- Spanish Ministerio de Economia y Competitividad [CTQ2016-78454-C2-1-R]
- NSERC
- Alberta Innovates
Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (O-1(2)) production. In this work, we report the next generation of metal-enhanced O-1(2) nanoplatforms exploiting the lightning rod effect, or plasmon hot spots, in anisotropic (nonspherical) metal nanoparticles. We describe the synthesis of Rose Bengal-decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) with silica shell thicknesses ranging from 5 to 50 nm based on an optimized protocol yielding highly homogeneous Ag NCs. Steady-state and time resolved O-1(2) measurements demonstrate not only the silica shell thickness dependence on the metal-enhanced O-1(2) production phenomenon but also the superiority of this next generation of nanoplatforms. A maximum enhancement of O-1(2) of approximately 12-fold is observed with a 10 nm silica shell, which is among the largest O-1(2) production metal enhancement factors ever reported for a colloidal suspension of nanoparticles. Finally, the Ag@SiO2-RB NCs were benchmarked against the Ag@SiO2-RB nanospheres previously reported by our group, and the superior O-1(2) production of Ag@SiO2-RB NCs resulted in improved antimicrobial activities in photodynamic inactivation experiments using both Gram-positive and-negative bacteria model strains.
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