期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 47, 页码 16360-16367出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b11218
关键词
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资金
- National University of Singapore [R-143-000-665-114, R-143-000-696-114, R-143-000-A30-112]
- Ministry of Education (MOE) of Singapore [R-143-000-665-114, R-143-000-696-114, R-143-000-A30-112]
- National Natural Science Foundation of China [21702142, 21771135, 21701119]
- GSK-EDB [R-143-000-687-592]
1,2-Disubstituted alkenes such as vinyl arenes, vinyl silanes, and vinyl boronates are among the most versatile building blocks that can be found in every sector of chemical science. We herein report a noble-metal-free method of accessing such olefins through a photo-induced decarboxylative Heck-type coupling using alkyl carboxylic acids, one of the most ubiquitous building blocks, as the feedstocks. This transformation was achieved in the absence of external oxidants through the synergistic combination of an organo photo-redox catalyst and a cobaloxime catalyst, with H-2 and CO2 as the only byproducts. Both control experiments and DFT calculations supported a radical-based mechanism, which eventually led to the development of a selective three component coupling of aliphatic carboxylic acids, acrylates, and vinyl arenes. More than 90 olefins across a wide range of functionalities were effectively synthesized with this simple protocol.
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