期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 24, 页码 14980-14985出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b00778
关键词
aerographite; tissue engineering; 3D scaffold; cyclic RGD; fibroblasts
资金
- European Union [330418]
- European Research Council under ERC [336104]
- German Research Foundation (DFG) [AD 183/17-1]
- DFG [SFB 986 M3]
- Deutscher Akademischer Austauschdienst (DAAD) [91526555-57048249]
- European Research Council (ERC) [336104] Funding Source: European Research Council (ERC)
Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days.
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