Production of submicron particles of the antioxidants of mango leaves/PVP by supercritical antisolvent extraction process

Mango leaves contain bioactive compounds of interest, due to their beneficial activity for health as antioxidant among others. These compounds can easily degrade by light or oxygen, for this reason, the encapsulation of antioxidant natural extract from these leaves is suggested as an effective approach against the degradation of phenolic compounds and to achieve a sustained release of them. The antioxidants/PVP encapsulates were obtained by supercritical antisolvent extraction process (SAE) using pressurized liquid extract (PLE). Using different conditions of pressure (120-180 bar), temperature (35-65 degrees C) and mass ratio (1/3-1/9), spherical particles were obtained in a submicronic range between 0.11-0.59 mu m. Antioxidants/PVP ratio was the most significance variable on the particle size and on the time of release of the mangiferin, quercetin 3-D-galactoside and penta-O-galloyl glucose, what means as greater amount of polymer higher particle size and smaller percentage of release.