期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 34, 页码 22025-22031出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b06415
关键词
bactericidal surfaces; microbial contamination; nanostructures; competitive colonization; inflammatory response
资金
- SNAL Marie Curie ITN Network of the Seventh Framework Program of the European Commission
With an aging population and the consequent increasing use of medical implants, managing, the possible infections arising from implant surgery remains a global challenge. Here, we demonstrate for the first time that a precise nanotopology provides an effective intervention in bacterial cocolonization enabling the proliferation of eukaryotic cells on a substratum surface, preinfected by both live Gram-negative, Pseudomonas aeruginosa, and Gram-positive, Staphylococcus aureus, pathogenic bacteria. The topology of the Model black silicon (bSi) substratum not only favors the proliferation of eukaryotic cells but is biocompatible, not triggering an inflammatory response in the host. The attachment behavior and development of filopodia when COS-7 fibroblast cells are placed in contact with the bSi surface are demonstrated in the dynamic study, which is based on the use of real-time sequential confocal imaging. Bactericidal nanotopology may enhance the prospect for further development of inherently responsive antibacterial nanomaterials for bionic applications such as prosthetics and implants.
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