期刊
JOURNAL OF SEPARATION SCIENCE
卷 42, 期 6, 页码 1163-1173出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201801201
关键词
cinnamamide; quadrupole time-of-flight tandem mass spectrometry; Scopolia tangutica; tropane alkaloids
资金
- National Natural Science Foundation of China [U1508221, 21405155, 31670374]
- DICP-CMC Innovation Institute of Medicine
- [DICP TMSR201601]
Scopolia tangutica is a traditional Chinese medicine used for antispasmodic, anesthesia, analgesia, and sedation. Its medicinal activity is associated to alkaloid constituents, including tropane and cinnamamide types. Low content of alkaloids in plant makes them difficult to be isolated and identified. The present work developed an effective method to quickly characterize alkaloids from Scopolia tangutica by highperformance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Thirteen reference compounds were studied for their fragmentation pathways, including five tropane alkaloids and eight cinnamamide ones. Alkaloid constituent was analyzed by an optimized high-performance liquid chromatography method and mass spectrometry analysis to achieve systematic characterization of alkaloids fromScopolia tangutica. As a result, 53 compoundswere identified, including 21 tropane alkaloids (eight new ones), 18 caffeoyl ones (ten new ones) and 14 dicaffeoyl ones (seven new ones). It was important to provide rich information in phytochemical study and structure-guided isolation of important compounds from this plant.
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