期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 7, 页码 4357-4367出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b00606
关键词
bioglass cones; sputtering; surfaces; structure; submicrometer needles
资金
- Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI [PN-II-RU-TE-2011-4-0164 (49/2011), PN-II-RU-TE-2014-4-0180 (73/2015)]
- CICECO
- CICECO-Aveiro Institute of Materials [UID/CTM/50011/2013]
- FEDER funds through the Operational Programme Competitiveness Factors (COMPETE)
- Portuguese Foundation for Science and Technology (FCT)
This work reports on the unprecedented magnetron sputtering deposition of submicrometric hollow cones of bioactive glass at low temperature in the absence of any template or catalyst. The influence of sputtering conditions on the formation and development of bioglass cones was studied. It was shown that larger populations of well-developed cones could be achieved by increasing the argon sputtering pressure. A mechanism describing the growth of bioglass hollow cones is presented, offering the links for process control and reproducibility of the cone features. The composition, structure, and morphology of the as-synthesized hollow cones were investigated by energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), grazing incidence geometry X-ray diffraction (GIXRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM)-selected area electron diffraction (SAED). The in vitro biological performance, assessed by degradation tests (ISO 10993-14) and cytocompatibility assays (ISO 10993-5) in endothelial cell cultures, was excellent. This allied with resorbability and the unique morphological features make the submicrometer hollow cones interesting candidate material devices for focal transitory permeabilization of the blood brain barrier in the treatment of carcinoma and neurodegenerative disorders.
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