期刊
JOURNAL OF RAMAN SPECTROSCOPY
卷 50, 期 3, 页码 314-321出版社
WILEY
DOI: 10.1002/jrs.5519
关键词
biofluids; ferric citrate sensor; norepinephrine; pretreatment method; surface-enhanced resonance Raman spectroscopy
类别
资金
- National Science Foundation of China [21505138, 21571180]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09J18112]
- Key Discipline of Material Science and Engineering of Suzhou University [2017XJZDXK3, 2018szxydzxz02]
Norepinephrine (NE) is a kind of catecholamine neurotransmitter that participates significant function in living organism. Rapid and sensitive detection target in complex system is crucial in analytical science. A facile ferric citrate (CA-Fe (III)) sensor was designed successfully for sensitive detection of NE by surface-enhanced resonance Raman spectroscopy (SERRS) method. This CA-Fe (III) sensor was prepared by modifying Fe (III) on the surface of uniform Au nanoparticles (NPs) wrapped with citrate (CA) stabilizer. The implementation of NE selective detection is attributed to significant enhancement provided by Au NPs and additional enhancement provided by ligand-to-metal charge transfer between chromophore and analyte. In addition, a universal CH3OH, HCl, and petroleum ether added in sequence pretreatment method was developed and applied to purify and enrich the target in practical biological sample, realizing selective detection of NE in biofluids. This novel sensor combined with SERRS and pretreatment strategy not only amplifies the Raman signal of NE but also paves the way for pretreating sample in complex system.
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