期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 36, 页码 23542-23548出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b07450
关键词
aptamer; photoactivation; cancer site; fluorescent imaging; nucleolin; breast cancer
资金
- 973 Program [2012CB720600, 2012CB720603, 2012CB720605]
- National Natural Science Foundation of China (NSFC) [21432008, 91413109, 81373256, 91213302]
Early:cancer diagnosis is of great significance to relative cancer prevention and clinical therapy, and it is crucial to efficiently recognize cancerous tumor sites at the molecular level. Herein, we proposed a versatile and efficient strategy based on aptamer recognition and photoactivation imaging for cancer diagnosis. This is the first time that a visible light controlled photoactivatable aptamer-based platform has been applied for cancer diagnosis. The photoactivatable aptamer-based strategy can accurately detect nucleolin-overexpressed tumor cells and can be used for highly selective cancer cell screening and tissue imaging. This strategy is available for both formalin-fixed paraffin-embedded tissue specimens and frozen sections. Moreover, the photoactivation techniques showed great progress in more accurate and persistent imaging to the use of traditional fluorophores. Significantly, the application of this strategy can produce the same accurate results in tissue specimen analysis as with classical hematoxylin-eosin staining and immunohistochemical technology.
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