期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 10, 页码 6621-6628出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11317
关键词
carbon dots; tunable fluorescence; dual-emission nanohybrid; nanothermometry; living cells
资金
- National Natural Science Foundation of China [50925207, 51432006, 51503085]
- Ministry of Science and Technology of China for the International Science Linkages Program [2011DFG52970]
- Natural Science Foundation of Jiangsu Province, China [BK20140157]
- Changjiang Innovation Research Team [IRT14R23]
- Programme of Introducing Talents of Discipline to Universities (111 Project) [B13025]
- Australian Research Council (ARC)
The use of Carbon-dot-based dual-emission fluorescent nanohybrids (DEFNs) as versatile nanothermometry devices for spatially resolved temperature Measurements in living cells is demonstrated. The carbon dots (CDs) are prepared in the organic phase and display tunable photoluminescence (PL) across a wide visible range by adjusting the excitation wavelengths and extend of N-doping. DEFNs are formed in a straightforward fashion froth CDs (emitting blue PL) and gold nanoclusters (AuNCs, emitting red PL). The DEFNs display ideal single-excitation, dual-emission with two well resolved, intensity-comparable fluorescence peaks, and function in optical thermometry with high, reliability and accuracy by exploiting the temperature sensitivity of their fluorescence intensity ratio (blue/red), Furthermore, the DEFNs have been introduced into cells, exhibiting good biocompatibility, and have facilitated physiological temperature measurements in the range of 25-45 degrees C; the DEFNs can therefore function as non-contact tools for the accurate measurement of temperature and its gradient inside a living cell.
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