期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 597, 期 1, 页码 173-191出版社
WILEY
DOI: 10.1113/JP276976
关键词
acoustic communication; breathing pattern; neonatal vocalization
资金
- DFG Research Centre Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)
- Deutsche Forschungsgemeinschaft DFG [Hu797/7-1, Hu797/8-1]
- Volkswagen Foundation (VolkswagenStiftung)
Mouse models are instrumental with respect to determining the genetic basis and neural foundations of breathing regulation. To test the hypothesis that glycinergic synaptic inhibition is required for normal breathing and proper post-inspiratory activity, we analysed breathing and ultrasonic vocalization (USV) patterns in neonatal mice lacking the neuronal glycine transporter (GlyT2). GlyT2-knockout (KO) mice have a profound reduction of glycinergic synaptic currents already at birth, develop a severe motor phenotype and survive only until the second postnatal week. At this stage, GlyT2-KO mice are smaller, have a reduced respiratory rate and still display a neonatal breathing pattern with active expiration for the production of USV. By contrast, wild-type mice acquire different USV-associated breathing patterns that depend on post-inspiratory control of air flow. Nonetheless, USVs per se remain largely indistinguishable between both genotypes. We conclude that GlyT2-KO mice, despite the strong impairment of glycinergic inhibition, can produce sufficient expiratory airflow to produce ultrasonic vocalization.
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