期刊
JOURNAL OF PHYSICS-CONDENSED MATTER
卷 30, 期 46, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-648X/aae5aa
关键词
nanowire; biosensing; neuronal interface; bioelectronics
资金
- Occitanie Region through the RBIO project
- Idex UNITI (Transversally program)
- CNRS (PEPS INSIS)
- French RENATECH network (French national nanofabrication platform)
The continuous miniaturization of electronic components and the emergence of nanobiotechnology has opened new perspectives to monitor electrical activities at the single cell level. Here, we describe the creation of very high surface-to-volume ratio passive devices (vertical nanowire probes) using large-scale fabrication process, allowing to follow the electrical activity of manunalian neurons. Based on conventional silicon processing, the silicon nanowires were silicided in platinum in order to improve their electrochemical performances and to guarantee their biocompatibility. Very high signal to noise ratio was achieved (up to 2000) when measuring spontaneous action potentials. Moreover, this bio-platform was used to record the impact of various bio-chemical and electrical stimulations on neuronal activity. To conclude, this study proposes a thorough comparison of the characteristics and performances of these new nanowire-based nanoprobes with the main alternative systems published up to now.
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