期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 108, 期 5, 页码 1857-1871出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.xphs.2018.12.019
关键词
diosmin nanocrystal; wafers; sodium alginate; gelatin; diabetic ulcer; wound dressings
This work aimed at loading of diosmin nanocrystals into alginate-based wafers for treatment of highly exuding diabetic ulcer in rats using topical route of administration. For this purpose, different formulation variables and preparation techniques to enhance the flexibility and adhesion properties of the prepared sodium alginate (SA) wafers were carried out. The prepared wafers were characterized regarding hydration capacity, bioadhesion, scanning electron microscope, and Fourier-transform infrared spectroscopy. Efficacy of treating diabetic ulcer was studied using diabetic-induced rat model using streptozotocin. Results obtained showed that using SA:gelatin with 1.5%/1.5% w/w gave acceptable wafers with a sustained release of diosmin over 8 h. A complete re-epithelialization, well-organized dermal layers, well-formed granulation tissue, and mature collagen bundles were observed in treated rats. It was concluded that combination of gelatin with SA provided an excellent wafer as a promising medicated wound dressing holding diosmin nanocrystals while maintaining its stability. (C) 2019 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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