期刊
JOURNAL OF PEDIATRICS
卷 206, 期 -, 页码 78-82出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2018.10.020
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类别
资金
- National Institutes of Health (NIDDK) [1K01DK111665]
- NIH/NCATS Colorado CTSA [UL1 TR001082]
- Abbott Nutrition
- American Heart Association
- Beef Checkoff through the National Cattlemen's Beef Association
- National Pork Board
- Leprino foods
Objective To test the long-term effect on growth status at 24 months of age in formula-fed infants who were randomized to consume a meat- or dairy-based complementary diet from 5 to 12 months of age. Study design Observational assessments, including anthropometric, dietary, and blood biomarkers, were conducted at 24 months of age, 1 year after the intervention ended. Results The retention rate at 24 months of age was 84% for the meat group and 81% for the dairy group. Mean (+/- SD) protein intakes at 24 months of age were 4.1 +/- 1.2 and 4.0 +/- 1.1 g/kmeat (n = 27) and dairy (n = 26) groups, respectively, and comparable with the estimates of US population intake. At 24 months of age, weight-for-age z score did not differ significantly between groups and was similar to that at 12 months. Length-for-age z score remained significantly higher in the meat group compared with the dairy group, and the average length was 1.9 cm greater in the meat group. Weight-for-length z score also did not differ significantly between groups. Insulin-like growth factor 1 significantly increased from 12 to 24 months of age in both groups, but insulin-like growth factor binding protein 3 and blood urea nitrogen did not change significantly from 12 to 24 months of age and were comparable between groups. Conclusions The protein source-induced distinctive growth patterns observed during infancy persisted at 24 months of age, suggesting a potential long-term impact of early protein quality on growth trajectories in formula-fed infants.
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