期刊
JOURNAL OF PATHOLOGY
卷 247, 期 5, 页码 686-696出版社
WILEY
DOI: 10.1002/path.5211
关键词
lung development; type 2 immunity; alveolarisation; bronchopulmonary dysplasia; group 2 innate lymphoid cells; ILC2; postnatal development; stem cells; respiratory infection; macrophages
资金
- Australian Research Council Discovery Early Career Researcher Award [DE170100226]
- National Health and Medical Research Council
- Faculty of Health (Brawn), The University of Newcastle
- Australian Research Council [DE170100226] Funding Source: Australian Research Council
Lung development is a complex process mediated through the interaction of multiple cell types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into early adulthood. The process can be separated into five different developmental stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Whilst lung bud formation and branching morphogenesis have been studied extensively, the mechanisms of alveolarisation are incompletely understood. Aberrant lung development can lead to deleterious consequences for respiratory health such as bronchopulmonary dysplasia (BPD), a disease primarily affecting preterm neonates, which is characterised by increased pulmonary inflammation and disturbed alveolarisation. While the deleterious effects of type 1-mediated inflammatory responses on lung development have been well established, the role of type 2 responses in postnatal lung development remains poorly understood. Recent studies indicate that type 2-associated immune cells, such as group 2 innate lymphoid cells and alveolar macrophages, are increased in number during postnatal alveolarisation. Here, we present the current state of understanding of the postnatal stages of lung development and the key cell types and mediators known to be involved. We also provide an overview of how stem cells are involved in lung development and regeneration, and the negative influences of respiratory infections. Copyright (c) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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