期刊
JOURNAL OF PATHOLOGY
卷 247, 期 5, 页码 552-562出版社
WILEY
DOI: 10.1002/path.5199
关键词
breast cancer; triple negative; pathology; tumour-infiltrating lymphocytes; prognostic signatures; genomic signatures; OncotypeDX; MammaPrint; Prosigna; EndoPredict (EPclin); Breast Cancer Index; MapQuantDx; PD-1; PD-L1
资金
- National Health and Medical Research Council Program [APP1113867]
- Cancer Australia/National Breast Cancer Foundation PdCCRS grant [APP017931]
During the last decade, the genomics revolution has driven critical advances in molecular oncology and pathology, and a deeper appreciation of heterogeneity that is beginning to reshape our thinking around diagnostic classification. Recent developments have seen existing classification systems modified and improved where possible, gene-based diagnostics implemented and tumour-immune interactions modulated. We present a detailed discussion of this progress, including advances in the understanding of breast tumour classification, e.g. mixed ductal-lobular tumours and the spectrum of triple-negative breast cancer. The latest information on clinical trials and the implementation of gene-based diagnostics, including MammaPrint and Oncotype Dx and others, is synthesised, and emerging targeted therapies, as well as the burgeoning immuno-oncology field, and their relevance in breast cancer, are discussed. Copyright (c) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据