期刊
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
卷 43, 期 6, 页码 742-749出版社
WILEY
DOI: 10.1002/jpen.1469
关键词
enteral nutrition; feeding intolerance; inflammation; prokinetics; trauma
资金
- National Institute of Diabetes and Digestive and Kidney Diseases training grant [2T35DK007676-21A1]
- William Stamps Farish Fund
- Howell Family Foundation
- Institutional Developments for Enhancing Intelligent Specialization Grant from the Hungarian National Research, Development and Innovation Office [EFOP-3.6.2-16-2017-0006]
Background Although feeding intolerance is a common complication in trauma patients, the incidence, development, and effects are poorly understood. Methods We performed a retrospective study in which trauma patients were classified as having feeding intolerance based on time to reach feeding goal. Subsequently, we sorted patients by gastric residual volumes (GRVs) or symptoms of slowed gastrointestinal motility. Results One-third of trauma patients experienced delayed time to reach feeding goal after diet initiation. Delayed feeding was associated with prolonged intensive care unit (ICU) stays, increased readmission rates, and increased incidence of sepsis. Patients with elevated GRV (>500 mL) had significantly prolonged ICU and hospital stays and increase incidence of sepsis. Patients with >2 symptoms of slowed gastrointestinal motility had prolonged ICU and hospital stays, delayed time to reach feeding goals, significantly increased readmission rates, increased incidence of infectious and thromboembolic complications and sepsis, decreased serum prealbumin levels, and increased CRP levels. Conclusion Decreased gastrointestinal motility in trauma patients is associated with worse outcomes and increased systemic inflammation.
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