Organometal-catalyzed asymmetric Friedel-Crafts reactions

The Friedel-Crafts alkylation (F-CA) reaction is a distinct sort of C-C bond formations. It is often used for the formation of C-C bonds to aromatic rings in organic synthesis. Its enantioselective version frequently provides highly enantiomer as the expected products. Generally, this asymmetric variant of asymmetric Friedel-Craft alkylation (AF-CA) proceeds via an in situ metal catalyzed generation of an enamine as an intermediate. In this report, we are trying to highlight the applications of various optically pure metal catalysts in the AF-CA as a versatile synthetic strategy in asymmetric synthesis. Metal-catalyzed AF-CA was frequently found as an important and decisive step (steps) for the effective asymmetric synthesis of complex molecules, compounds showing interesting diverse biological activities and especially in the total synthesis of naturally occurring compounds with great and various biological and pharmacological properties. (C) 2018 Published by Elsevier B.V.