期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 24, 页码 15512-15523出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02442
关键词
-
资金
- NSFC [U1604283, 21778014]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [19HASTIT036]
- 111 Project [D17007]
An efficient method to construct chiral acyclic nucleosides via Sharpless asymmetric dihydroxylation of N-allylpyrimidines or N-alkenylpurines is reported. A range of chiral acyclic nucleosides with two adjacent hydroxyl groups present on the side chains could be produced in good yields (up to 97% yield) and excellent enantioselectivities (90-99% ee). The synthetic utility of the reaction was demonstrated by the catalytic asymmetric synthesis of (S)-Cidofovir and (R)-Buciclovir.
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