期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 23, 页码 14637-14645出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02464
关键词
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资金
- NIGMS [R01-GM073072]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM073072] Funding Source: NIH RePORTER
An N-heterocyclic carbene (NHC)-catalyzed reaction of gamma-substituted allenoates for the synthesis of substituted oxetanes has been developed. The method provides an approach to access substituted oxetanes in a single step and is the first example of an NHC-catalyzed formal [2+2]-annulation employing gamma-substituted allenoates with trifluoromethyl ketones. Mechanistic and modeling studies provide a rationale for the divergence in reactivity observed compared to the analogous reaction using unsubstituted allenoates and inform a hypothesis to explain the observed diastereoselectivity under different reaction conditions.
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