期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 21, 页码 13395-13401出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02172
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资金
- National Key R&D Program of China [2017YFE0102200]
- National Natural Science Foundation of China [81773587, 81773769, 81273428]
Penicipyrrodiether A, an adduct of GKK1032 analogue and phenol A derivative, was isolated from a culture of marine-associated fungus Penicillium sp. ZZ380 and represents the first example of this type of fungal metabolite. Its structure was elucidated by extensive spectroscopic analyses, including 1D- and 2D-NMR, HRESIMS, MS/MS, and electronic circular dichroism calculation as well as single-crystal X-ray diffraction. Penicipyrrodiether A showed antibacterial activity in inhibiting the growth of methicillin-resistant Staphylococcus aureus with a MIC value of 5.0 mu g/mL. Its plausible pathway for biosynthesis has been proposed.
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