期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 3, 页码 1320-1329出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02789
关键词
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资金
- European Regional Development Fund (ERDF) [1.1.1.2/VIAA/1/16/235]
- funding line strategic networks of the Leibniz Association
A straightforward two-step synthesis of benzoxepinones was developed via base-free phosphane-catalyzed Wittig reaction. 3-Methyl-1-phenyl-2-phospholene 1-oxide was used as a precatalyst and trimethoxysilane as a reducing agent. Additionally benzoic acid is employed as a catalyst to facilitate the reduction of the phosphane oxide. Mechanistic investigation revealed the formation of a coumarin as a side product, which was identified by 2D NMR experiments. First results of metabolic activity tests on the prepared benzoxepinones are reported.
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