期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 66, 期 -, 页码 43-51出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2019.01.007
关键词
Gut-brain axis; Short-chain fatty acids; Enterochromaffin cell; Microbiota; 5-Hydroxytryptophan
资金
- National Natural Science Foundation of China [31671839, 31820103010]
- Fundamental Research Funds for the Central Universities [JUSRP51501]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180102]
Depression disorder is rapidly advancing worldwide, and therapeutic strategy through gut-brain axis has been proven to be effective in the treatment. Here we studied the effect of lactic acid bacteria (LAB) treatment on depression. C57BL/6J mice were administered with LAB during a 5-week chronic unpredictable mild stress. Bifidobacterium longum subsp. infantis E41 and Bifidobacterium breve M2CF22M7, which improved the expression of Tphl and secretion of 5-hydroxytryptophan (5-HTP) in RIN14B cells, significantly reduced depressive behaviors of mice in the forced swim test, sucrose preference test and step-down test, as well as increased the level of 5-hydroxytryptamine and brain-derived neurotrophic factor concentration in brain. Besides, M2CF22M7 reduced the serum corticosterone level. E41 increased cecal butyrate level, which significantly and positively correlated with some depression-related indexes. Using 16S rRNA-amplicon sequencing of faces, E41 and M2CF22M7 were found to improve the chronic-stress-induced microbial dysbiosis. They also normalized the host's pathways involving metabolism and gene information processing. These results indicate that Bifidobacterium E41 and M2CF22M7 have an antidepressant effect in mice partly in a 5-HTP dependent and microbiota-regulating manner. Nurturing the gut microbiota with these strains may become an emerging therapeutic way for mood disorder. (C) 2019 Elsevier Inc. All rights reserved.
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