期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 44, 页码 9433-9445出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1674-18.2018
关键词
motivation; threat; reward; development; early life stress; prefrontal cortex; dopamine
资金
- National Institutes of Health Director's Early Independence Award [DP5OD021370]
- National Institute of Mental Health R61 Grant [R61MH115113]
- Brain and Behavior Research Foundation Young Investigator Grant
- Klingenstein-Simons Fellowship Award
- National Science Foundation [1654393]
- Jacobs Foundation Early Career Fellowship
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [1654393] Funding Source: National Science Foundation
The ability to anticipate and respond appropriately to the challenges and opportunities present in our environments is critical for adaptive behavior. Recent methodological innovations have led to substantial advances in our understanding of the neurocircuitry supporting such motivated behavior in adulthood. However, the neural circuits and cognitive processes that enable threat- and reward-motivated behavior undergo substantive changes over the course of development, and these changes are less well understood. In this article, we highlight recent research in human and animal models demonstrating how developmental changes in prefrontal-subcortical neural circuits give rise to corresponding changes in the processing of threats and rewards from infancy to adulthood. We discuss how these developmental trajectories are altered by experiential factors, such as early-life stress, and highlight the relevance of this research for understanding the developmental onset and treatment of psychiatric disorders characterized by dysregulation of motivated behavior.
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