期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 47, 页码 10102-10113出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1122-18.2018
关键词
aggrecan; inhibitory; interneuron; neuronal plasticity; parvalbumin; perineuronal nets
资金
- Alzheimer's Research UK [ARUK-RF2016A-1]
- Christopher and Dana Reeve Foundation
- Research Council of Norway [143543, 143730, 549217, 231248]
- University of Oslo
- BBSRC [BB/N008189/1] Funding Source: UKRI
- MRC [MR/R004463/1, MR/R004544/1] Funding Source: UKRI
In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan using a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin-expressing inhibitory interneurons toward a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.
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