期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 46, 页码 9870-9882出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1216-18.2018
关键词
calretinin; neurogenesis; olfactory bulb; periglomerular cell
资金
- Centre National pour la Recherche Scientifique
- Universite de Strasbourg
- Agence Nationale pour la Recherche [ANR-12-JSV4-006-01]
- Ministere de la Recherche
- Fonds Paul Mandel pour les Recherches en Neuroscience
- Programme Avenir Lyon Saint-Etienne
Calretinin (CR)-expressing periglomerular (PG) cells are the most abundant interneurons in the glomerular layer of the olfactory bulb. They are predominately generated postnatally from the septal and dorsal subventricular zones that continue producing them well into adulthood. Yet, little is known about their properties and functions. Using transgenic approaches and patch-clamp recording in mice of both sexes we show that CR( + ) PG cells of both septal and dorsal origin have homogeneous morphological and electrophysiological properties. However, unlike other PG cells, these axonless neurons express a surprisingly small repertoire of voltage-activated channels and do not fire or fire at most a single and often small action potential. Moreover, they are not innervated by olfactory sensory neurons and receive little synaptic inputs from mitral or tufted cells at excitatory synapses where NMDA receptors predominate. These membrane and synaptic properties, that resemble those of newborn immature neurons not yet integrated in the network, persist over time and limit the recruitment of CR( + ) PG cells by afferent inputs that strongly drive local network activity. Together, our results show that postnatally generated CR( + ) PG cells continuously supply a large pool of neurons with unconventional properties. These data also question the contribution of CR( + ) PG cells in olfactory bulb computation.
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