期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 6, 页码 984-1004出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2557-18.2018
关键词
auditory pathway; cochlear nucleus; inferior colliculus; Neurod1 mutation; plasticity; sensory topographical map
资金
- Czech Science Foundation [17-04719S]
- ERDF [BIOCEVCZ.1.05/1.1.00/02.0109]
- Czech Academy of Sciences [RVO: 86652036]
- Charles University [GA UK 324615, GAUK 780216]
- NIH [R01 AG060504]
Hearing depends on extracting frequency, intensity, and temporal properties from sound to generate an auditory map for acoustical signal processing. How physiology intersects with molecular specification to fine tune the developing properties of the auditory system that enable these aspects remains unclear. We made a novel conditional deletion model that eliminates the transcription factor NEUROD1 exclusively in the ear. These mice (both sexes) develop a truncated frequency range with no neuroanatomically recognizable mapping of spiral ganglion neurons onto distinct locations in the cochlea nor a cochleotopic map presenting topographically discrete projections to the cochlear nuclei. The disorganized primary cochleotopic map alters tuning properties of the inferior colliculus units, which display abnormal frequency, intensity, and temporal sound coding. At the behavioral level, animals show alterations in the acoustic startle response, consistent with altered neuroanatomical and physiological properties. We demonstrate that absence of the primary afferent topology during embryonic development leads to dysfunctional tonotopy of the auditory system. Such effects have never been investigated in other sensory systems because of the lack of comparable single gene mutation models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据