期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 77, 期 12, 页码 1091-1100出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/nly092
关键词
Amyotrophic lateral sclerosis; Chronic traumatic encephalopathy; Military veterans; Motor neuron degeneration; Motor neuron disease; Traumatic brain injury
资金
- Department of Veterans Affairs, Veterans Health Administration, Veterans Affairs Biorepository [BX002466]
- Clinical Sciences Research and Development Merit Award [I01-CX001038]
- National Center for PTSD
- National Institute of Aging [RF1AG054156, R56AG057768]
- National Institute of Aging Boston University AD Center [P30AG13846, 0572063345-5]
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive head impacts and has been associated with amyotrophic lateral sclerosis (ALS), a fatal, degenerative neuromuscular disorder. The Department of Veterans Affairs Biorepository Brain Bank (VABBB) is a tissue repository that collects antemortem disease progression data and postmortem central nervous system tissue from veterans with ALS. We set out to determine the frequency of co-morbid ALS and CTE in the VABBB cohort and to characterize the clinical, genetic, and pathological distinctions between participants with ALS only and those with both ALS and CTE (ALS+CTE). Of 155 participants, 9 (5.8%) had neuropathologically confirmed ALS+CTE. Participants with ALS+CTE were more likely to have a history of traumatic brain injury (p < 0.001), served during the first Persian Gulf War (p < 0.05), and to have more severe tau pathology within the frontal cortex and spinal cord (p < 0.05). The most common exposures to head impacts included contact sports (n = 5) and military service (n = 2). Clinically, participants with ALSthornCTE were more likely to have bulbar onset ALS (p = 0.006), behavioral changes (p = 0.002), and/or mood changes (p < 0.001). Overall, compared with ALS in isolation, comorbid ALS+CTE is associated with a history of TBI and has a distinct clinical and pathological presentation.
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