期刊
JOURNAL OF NEURAL TRANSMISSION
卷 126, 期 4, 页码 433-448出版社
SPRINGER WIEN
DOI: 10.1007/s00702-018-1952-7
关键词
MAO-B; COMT; L-DOPA; Dopamine synthesis; Dyskinesia
MAO-B and COMT are both enzymes involved in dopamine breakdown and metabolism. Inhibitors of these enzymes are used in the treatment of Parkinson's disease. This review article describes the scientific background to the localization and function of the enzymes, the physiological changes resulting from their inhibition, and the basic and clinical pharmacology of the various inhibitors and their role in treatment of Parkinson's disease.
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