期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 11, 页码 2392-2398出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00373
关键词
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资金
- DFG [GRK 2158]
- Manchot Foundation
- EU
- European Regional Development Fund [GINOP-2.3.2-15-2016-00008]
The first members of a new alkaloid class, chaetolines A (1) and B (2), which feature a pyrano[3,2-f]isoquinoline core structure, were obtained from a crude extract of the fungal endophyte Chaetomium sp. after cultivation in the presence of autoclaved Pseudomonas aeruginosa. The structures of the new compounds, including the absolute configuration of the major stereoisomer, were determined through detailed analysis of HRESIMS, 1D/2D NMR, and calculation of ECD data. The possible biosynthetic origin of the unprecedented scaffold of 1 and 2 is proposed. The current study provides further evidence for mixed fermentation as a powerful tool to induce the accumulation of cryptic fungal natural products even in the absence of viable bacterial cells.
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