期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 10, 页码 2222-2227出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00473
关键词
-
资金
- Egyptian Government
- National Center for Natural Products Research, University of Mississippi, USA
- USDA Agricultural Research Service [58-6060-6-015]
- U.S. National Institutes of Health [P20GM104932]
- National Science Foundation Major Research Infrastructure grant [1338056]
- NIH [C06RR14503]
Two new carbasugar-type metabolites, (1S,2R,3R,4R,5R)-2,3,4-trihydroxy-5-methylcyclohexy1-2',5'-dihydroxybenzoate (1) and (1S,2S,3S,4R,5R)-4-[(2',5'-dihydroxybenzyl)oxy]-5-methylcyclohexane-1,2,3-triol (2), were isolated from the filamentous fungus Geosmithia langdonii isolated from cotton textiles from Assiut, Egypt. The structures of 1 and 2 were elucidated based on comprehensive 1D and 2D NMR and MS data. Compounds 1 and 2 showed antileishmanial activity against Leishmania donovani with IC50 values of 100 and 57 mu M respectively. The (1S,2R,3R,4R,5R) absolute configuration of carbasugar 1 was assigned via 2D NMR and experimental and calculated electronic circular dichroism (ECD) data. Similarly, the tentative structure of compound 2 was shown to possess a (1S,2S,3S,4R,5R) absolute configuration via comparing its experimental ECD data and the specific rotation with 1 as well as examining the energy-minimized 3D computational models of compounds 1 and 2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据