期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 431, 期 18, 页码 3547-3567出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.12.015
关键词
peptide design; antimicrobial peptides; design principles; physicochemical features; antibiotic resistance
资金
- Ramon Areces Foundation
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Brazil) [2014/04507-5, 2016/24413-0]
- DTRA HDTRA [1-15-1-0050]
- National Institutes of Health
- Defense Threat Reduction Agency
- Defense Advanced Research Projects Agency
- Kenneth Rainin Foundation
- Koch Institute for Integrative Cancer Research
- Broad Institute of MIT and Harvard
- Center for Microbiome Informatics and Therapeutics
- National Science Foundation
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/04507-5] Funding Source: FAPESP
The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel anti-infective therapies. Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics. AMPs are versatile, have almost unlimited sequence space, and can be tuned for broad-spectrum or specific activity against microorganisms. However, several obstacles remain to be overcome in order to develop AMPs for medical use, such as toxicity, stability, and bacterial resistance. We lack standard experimental procedures for quantifying AMP activity and do not yet have a clear picture of the mechanisms of action of AMPs. The rational design of AMPs can help solve these issues and enable their use as new antimicrobials. Here we provide an overview of the main physicochemical features that can be engineered to achieve enhanced bioactivity and describe current strategies being used to design AMPs. (C) 2018 Published by Elsevier Ltd.
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