期刊
JOURNAL OF MEMBRANE SCIENCE
卷 570, 期 -, 页码 85-92出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.memsci.2018.10.022
关键词
-
资金
- Deutsche Forschungsgemeinschaft (DFG) [KR 3902/2-2]
In this study, we present hydrophobic yttria-stabilized zirconia capillary membranes conditioned for virus filtration. These macroporous ceramic filters (d(50) = 150 nm) efficiently extract viruses regardless of their surface charge with high throughput rates. For hydrophobic functionalization of the ceramic membranes we used two different silanes, n-hexyltriethoxysilane (HTS, C6-chain) and n-octyltriethoxysilane (OTS, C8-chain), in three different molarities. The virus retention of the membranes is tested in dead-end mode by intracapillary virus feeding using two small bacteriophages as model species: MS2 and PhiX174. Virus retention increases most strongly for hydrophobic capillaries functionalized with 0.05 M OTS, showing a virtually complete retention with log-reduction values (LRVs) of similar to 9 for both bacteriophages compared to the non-functionalized membrane with LRVs of 0.3 +/- 0.1 for MS2 and 3.4 +/- 0.2 for PhiX174. The functionalized membranes allow a high membrane flux of similar to 150 L/(m(2) hbar), with throughput rates up to similar to 400 L/(m(2) h) while maintaining high filtration efficiency. Even under varying feed conditions using only mono- or divalent salt ions or pH values ranging from 3 to 9, retention capacities of the capillary membranes are high. Accordingly, such hydrophobic ceramic membranes offer a versatile alternative to conventional polymeric membranes for virus removal with greatly improved membrane flux.
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