期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 62, 期 4, 页码 2049-2059出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.8b01682
关键词
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资金
- NSFC [81773674, 81573383, 21390402]
- NSFHP [2017CFA024, 2017CFB711, 2016ACA126]
- ABRPSTCS [SYG201521]
- NSFJP [BK20160387]
- Shenzhen Science and Technology Research Grant [JCYJ20170303170809222]
- Office of Science (BER), the U.S. Department of Energy [DE-SC0008397]
- NIH ICMIC grant [P50 CA114747]
- Fundamental Research Funds for the Central Universities
- Open Research Fund Program of the Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals
- China Scholarship Council
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIRII window. Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. The signal background ratio and the tumor normal tissue ratio achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.
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